and Genetic Factors in EDS and Related Connective Tissue Disorders
to my site on health, logic and hereditary connective tissue disorders.
I started the research for this web site after I was diagnosed with
Ehlers-Danlos syndrome, a genetic disorder with no known cure.
In researching Ehlers-Danlos syndrome and related disorders, I found
that much of the hereditary connective tissue disorder research is based
on the premise that the various disorders are each caused by single
genes unrelated to each other and unrelated to environmental factors.
After spending a lot of time researching
Ehlers-Danlos syndrome, related disorders, and the field of genetics
in general, I disagree with this premise. I found lots of
links between EDS and environmental factors, especially nutrition. I used
much of this research to improve my own condition and that of my children,
and I think there is every reason to think that environmental factors
may be considerations for others with Ehlers-Danlos syndrome and similar
connective tissue disorders.
The concept that inherited disorders are
caused by a single defective gene is no longer widely accepted in most
genetic research and literature. The $60 million Environmental
Genome Project is based on the concept that few disorders are caused
by a single genetic or environmental event. The premise of the
Environmental Genome Project, an outgrowth of the Human Genome Project,
is that most disorders are in reality caused by complex sets of interactions
between genetic and environmental factors.
One line of thinking in science that is
currently gaining in popularity is that some diseases occur because
genes may not be the best suited for our new, modern day environments.
Perhaps instead of trying to make our genes fit our environments with
gene therapy, we just need to change our environment, including our
diets, to fit our genes. We know from experience in disorders
such as cancer, that genetic factors may increase a person's susceptibility
to contracting a disorder, but that this susceptibility can be greatly
reduced through appropriate dietary and other environmental modifications.
Curiously, there has been little, if any,
environmental research on most inherited connective tissue disorders.
However, there is no reason to think that environmental influences would
not be important factors, especially since many of the individual features
of connective tissue disorders, such as mitral valve prolapse, blue sclerae,
pectus excavatum, dislocated lenses, aortic aneurysms and osteopenia,
have each been clearly linked to nutritional deficiencies.
In any case, most of the considerations in this Web site, such as reading
well written nutrition books and working with your doctor to determine
if you have any food allergies and/or nutritional deficiencies, are generally
all healthy things to do anyway, and some may end up helping your genetic
disorder symptoms, too.
My goals in putting up this Web site are:
To share the environmental
links I uncovered with others who may have some of the same conditions
To distribute my theories
To encourage more
research into controllable environmental factors, especially nutrition,
and hereditary connective tissue disorders.
Questions and Commonalties About Hereditary Connective Tissue Disorders
and Related Hereditary Connective Tissue Disorder Features Include: